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Химия Anaesthetic Ether
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Ether

H3C O CH3

C4H10O 74.1

When solvent ether is demanded, Ether shall be supplied.

DEFINITION

Ether is diethyl ether which may contain a suitable non-volatile antioxidant at a suitable concentration.

CHARACTERS

A clear, colourless liquid, volatile, highly flammable, soluble in water, miscible with alcohol, with

methylene chloride and with fatty oils.

IDENTIFICATION

A. It complies with the test for relative density (see Tests).

B. It complies with the test for distillation range (see Tests).

TESTS

AcidityTo 20 ml of alcohol R add 0.25 ml of bromothymol blue solution R1 and, dropwise, 0.02M

sodium hydroxide until a blue colour persists for 30 s. Add 25 ml of the substance to be examined,

shake and add, dropwise, 0.02M sodium hydroxide until the blue colour reappears and persists for 30 s.

Not more than 0.4 ml of 0.02M sodium hydroxide is required.

Relative density(2.2.5): 0.714 to 0.716.

Distillation range(2.2.11). Do not distil if the substance to be examined does not comply with the test for peroxides. It distils completely between 34.0°C and 35.0°C. Carry out the test using a suitable heating device and taking care to avoid directly heating the flask above the level of the liquid.

Non-volatile matterAfter ensuring that the substance to be examined complies with the test for peroxides, evaporate 50 ml to dryness on a water-bath and dry the residue in an oven at 100°C to 105°C. The residue weighs not more than 1 mg (20 mg/l).

Substances with a foreign odourMoisten a disc of filter paper 80 mm in diameter with 5 ml of the

substance to be examined and allow to evaporate. No foreign odour is perceptible immediately after

the evaporation.

AldehydesTo 10.0 ml in a ground-glass-stoppered cylinder add 1 ml of alkaline potassium

tetraiodomercurate solution R and shake for 10 s. Allow to stand for 5 min, protected from light. The lower layer may show yellow or reddish-brown opalescence but not grey or black opalescence.

PeroxidesPlace 8 ml of potassium iodide and starch solution R in a 12 ml ground-glass-stoppered

cylinder about 15 mm in diameter. Fill completely with the substance to be examined, mix and allow to stand protected from light for 5 min. No colour develops.

Water(2.5.12). Not more than 2 g/l, determined on 20 ml by the semi-micro determination of

water.

STORAGE

Store in an airtight container, protected from light, at a temperature of 8°C to 15°C.

LABELLING

The label states, where appropriate, the name and concentration of any added non-volatile

antioxidant.

C4H10O 74.1

DEFINITION

Anaesthetic ether is diethyl ether which may contain a suitable non-volatile antioxidant at an

appropriate concentration.

CHARACTERS

A clear, colourless liquid, volatile, very mobile, highly flammable, soluble in 15 parts of water,

miscible with alcohol and with fatty oils.

IDENTIFICATION

A. It complies with the test for relative density (see Tests).

B. It complies with the test for distillation range (see Tests).

TESTS

Relative density(2.2.5): 0.714 to 0.716.

Distillation range(2.2.11). Do not distil if the substance to be examined does not comply with the test for peroxides. It distils completely between 34.0°C and 35.0°C. Carry out the test using a suitable heating device and taking care to avoid directly heating the flask above the level of the liquid.

Non-volatile matterAfter ensuring that the substance to be examined complies with the test for peroxides, evaporate 50 ml to dryness on a water-bath and dry the residue at 100°C to 105°C. The residue weighs not more than 1 mg (20 mg/l).

Substances with a foreign odourMoisten a disc of filter paper 80 mm in diameter with 5 ml of the

substance to be examined and allow to evaporate. No foreign odour is perceptible immediately after

the evaporation.

AcidsTo 20 ml of alcohol R add 0.25 ml of bromothymol blue solution R1 and, dropwise, 0.02M sodium hydroxide until a blue colour persists for 30 s. Add 25 ml of the substance to be examined, shake and add, dropwise, 0.02M sodium hydroxide until the blue colour reappears and persists for 30 s. Not more than 0.4 ml of 0.02M sodium hydroxide is required.

Acetone and aldehydesTo 10.0 ml in a ground-glass-stoppered cylinder add 1 ml of alkaline

potassium tetra-iodomercurate solution R and shake for 10 s. Allow to stand for 5 min, protected from light. The lower layer shows only a slight opalescence.

If the substance to be examined does not comply with the test, distil 40 ml, after ensuring that the

substance to be examined complies with the test for peroxides, until only 5 ml remains. Collect the distillate in a receiver cooled by placing in a bath of iced water and repeat the test described above using 10.0 ml of the distillate.

PeroxidesPlace 8 ml of potassium iodide and starch solution R in a 12 ml ground-glass-stoppered

cylinder about 15 mm in diameter. Fill completely with the substance to be examined, shake

vigorously and allow to stand protected from light for 30 min. No colour is produced.

Water(2.5.12). Not more than 2 g/l, determined on 20 ml by the semi-micro determination of

water.

STORAGE

Store in an airtight container, protected from light, at a temperature of 8°C to 15°C. The contents of

a partly filled container may deteriorate rapidly.

LABELLING

The label states, where appropriate, the name and concentration of any added non-volatile

antioxidant.

Приложение 13


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    Ether H3C O CH3 C4H10O 74.1 When solvent ether is demanded, Ether shall be supplied. DEFINITION Ether is diethyl ether which may contain a suitable non-volatile antioxidant at a suitable concentration. CHARACTERS A clear, colourless liquid, volatile, highly flammable, soluble in water, miscible with alcohol, with methylene chloride and with fatty oils. IDENTIFICATION A. It complies with the test for relative density (see Tests). B. It complies with the test for... [читать подробенее]